The show centers around the collaborative efforts of British and American officials as they work together to uncover the truth behind the tragic terrorist attack in Lockerbie on December 21, 1988. This attack, which resulted in the deaths of 270 individuals aboard Pan Am Flight 103, remains the deadliest terrorist act in UK history. Viewers witness Detective Ed MacKasker and FBI agent Dick Marquis as they navigate through bureaucratic challenges, international complexities, and emotional turmoil while conducting their investigation.